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Publications

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 43. Rapid Capture of Peptide Binders

Calvert, SH; McGouran, JF.

Nature Reviews Chemistry, 2023, doi: 10.1038/s41570-023-00517-7

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 42. Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A

Arbour, CA; Fay, EM; McGouran, JF, Imperiali, B.

Organic & Biomolecular Chemistry, 2023, 21, 5873-5879

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 41. Exploring the binding pockets of the DNA damage repair enzyme SNM1A through nucleobase modification

Fay, EM; McGouran, JF.

Results in Chemistry, 2023, 5, 100939

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 40. Two-Step Validation Approach for Tools to Study the DNA Repair Enzyme SNM1A

Fay, EM; Newton, A; Berney, M; El-Sagheer, A; Brown, T; McGouran, JF.

ChemBioChem, 2023, e202200756

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39. 5'-Phosphorylation increases the efficacy of nucleoside inhibitors of the DNA repair enzyme SNM1A

Berney, M; Manoj, MT; Fay, EM; McGouran, JF.

ChemMedChem, 2022, e202100603

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38. Flipping the switch: Innovations in inducible probes for protein profiling

McKenna, SM; Fay, EM; McGouran, JF

ACS Chem. Biol, 2021

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37. Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A

Berney, M; Doherty, W; Jauslin, WT; Manoj, MT; D​ürr, EM; McGouran, JF.

Bioorganic and Medicinal Chemistry, 2021, 46, 116369

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35. Probing the binding requirements of modified nucleosides with the DNA nuclease SNM1A

Dürr, EM; McGouran, JF.

Molecules, 2021, 26 (2), 320 

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34. Probing enzyme activity - a radical approach

Taylor, NC.; Hessman, G; Kramer, HB.; McGouran, JF.

Chemical Science, 2020, 11, 2967 

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33. Strategies to target specific components of the ubiquitin conjugation/ deconjugation machinery

Taylor, NC.; McGouran, JF.

Frontiers in Chemistry, 2019, 7 

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32. Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Thomas, A; Brolih, S; McGouran, JF.; El-Sagheer, A; Ptchelkine, D; Jones, M; McDonald, N; McHugh, P; Brown, T

Chemical Comminications, 2019, 55, 11671-11674

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31. A hydroxamic-acid-containing nucleoside inhibits DNA nuclease SNM1A

Doherty, W; Dürr, EM.; Baddock, HT.; Lee, SY.; McHugh, PJ.; Brown, T; Senge MO.; Scanlan, EM.; McGouran JF.

Organic & Biomolecular Chemistry, 2019, 17 (35), 8021-8262

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30. Human Platelet Protein Ubiquitylation and Changes following GPVI activation

Unsworth, AJ.; Bombik, I; McGouran, JF.; Konietzy, R; Zahedi, RP.; Watson, SP.; Kessler, BM.; Pears, C

Thrombosis and Haemostasis, 2019, 119(1), 104-116

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29. Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

Dürr, EM.; Doherty, W; Lee, SY.; El-Sagheer, AH.; Shivalingam, A; McHugh, PJ.; Brown, T; McGouran, JF.

Chemistry Select, 2018, 3, 12824-12829

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28. Dengue Virus Stimulation of Dendritic Cells Induces Phosphorylation- and Proteolysis-dependent Signalling 

Howles, A; McGouran, JF.; Kessler, BM.; Luhn K

Malaysian Journal of Microbiology, 2018, 14(6), 474-482

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27. Methods for Detection of Cytosine and Thymine Modifications in DNA

Berney, M; McGouran, JF. 

Nature Reviews Chemistry, 2018, 2, 332-348

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26. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, EL.; Ryan, DG.;  Prag, HA.; Dikovskaya, D; Menon, D; Zaslona, Z; Jedrychowski, MP.; Costa, AS.H.; Higgins, M,; Hams, E; Szpyt, J; Runtsch, MC; King, MS; McGouran, JF; Fischer, R; Kessler, BM; McGettrick, AF; Hughes, MM; Carroll, RG; Booty, LM; Knatko, EV; Meakin, PJ; Ashford, MLJ; Modis, LK; Brunori, G; Sévin, DC; Fallon, PG; Caldwell, ST; Kunji, ERS; Chouchani, ET; Frezza, C; Dinkova-Kostova, AT; Hartley, RC; Murphy, MP; O’Neil, LA

Nature, 2018, 556, 113-117

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25. Molecular basis of USP7 inhibition by selective small-molecular inhibitors

Turnbull AP, Ioannidis S, Krajewski WW, PintoFernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia Jr DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL,  Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S,  Urbé S, Clague MJ, Kessler BM, Komander D

Nature, 2017, 550, 481-486

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24. RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

Abdullah, UB; McGouran, JF; Brolih, S; Ptchelkine, D; El-Sagheer, AH; Brown, T; McHugh, PJ

The EMBO Journal, 2017, 36, 2047-2060

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23. Phosphorylation induces structural changes in the Autographa californica Nucleopolyhedrovirus P10 protein

Raza, F; McGouran, JF; Kessler, BM; Possee, RD; King, LA

Journal of Virology, 2017, 91(13 ), 1-15

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22. Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells

Kessler, BM; Bursmanno, S; McGouran, JF; Hickson, ID; Liu, Y

Methods in Molecular Biology, 141, Activity Based Proteomics, p 131-144. Book Chapter

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21. Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents

Evans, P; Doherty, W; Adler, N; Knox, A; Nolan, D; McGouran, JF; Nikalje, AP; Sarkate, A

European Journal of Organic Chemistry, 2016, 1, 175-185

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20. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response

Ghari, F; Quirke, AM; Munro, S; Kawalkowska, J, Picaud, S; McGouran, JF; Subramanian, V; Muth, A; Williams, R; Kessler, BM; Thompson, PR; Fillipakopoulos, P; Knapp, S; Venables, PJ; La Thangue, NB.

Science Advances, 2016, 2(2), pe1501257

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19. Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cell

Grijzenhout, A; Godwin, J;  Koseki, H; Gdula, M; Szumska, D; McGouran, JF; Bhattacharya, S; Kessler, BM; Brockdorff, N; Cooper, S.

Development, 2016, 143, 2716-2723

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18. DNA-PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair

Ying, S; Chen, Z; Medhurst, AL; Neal, JA; Bao, Z; Mortusewicz, O; McGouran, J; Song, X; Shen, H; Hamdy, FC; Kessler, BM; Meek, K; Helleday, T

Cancer Research, 2016, 76(5), 1078-1088

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17.  Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase

Maniam, S; Coutts, AS; Stratford, MR; McGouran, JF; Kessler, BM; La Thangue, NB

Cell Death & Differentation, 2015, 22, 156-163

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16. Regulation of SUMO2 target proteins by the Proteasome in Human Cells Exposed to Replication Stress

Bursomanno, S; McGouran, JF; Kessler, BM; Hickson, ID; Liu, Y

Journal of Proteome Research, 2015, 14(4), 1687-1699

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15. Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Watson, AS; Riffelmacher, T; Stranks, A; Williams, O; De Boer, J; Cain, K; MacFarlane, M; McGouran, J; Kessler, B; Khandwala, S; Chowdhury, O; Puleston, D; Phadwal, K; Mortensen, M; Ferguson, D; Soilleux, E; Woll, P

Cell Death Discovery, 2015, 1, Article Number: 15008

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14. Genetic control of differential acetylation in diabetic rats

Kaisaki, PJ; Otto, GW; McGouran, JF; Toubal, A; Argoud, K; Waller-Evans, H; Finlay, C; Caldérari, S; Bihoreau, MT; Kessler, BM; Gauguier, D; Mott, R

PloS One, 2014, 9(4), pe94555

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13. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation

Blackledge, NP; Farcas, AM; Kondo, T; King, HW; McGouran, JF; Hanssen, LL; Ito, S; Cooper, S; Kondo, K; Koseki, Y; Ishikura, T; Long, HK; Sheahan, TW; Brockdorff, N; Kessler, BM; Koseki, H; Klose, RJ.

Cell, 2014, 157, (6), 1445-1459

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12. Comparison of Neutralizing Antibody Responses Elicited from Highly Diverse Polyvalent Heterotrimeric HIV-1 gp140 Cocktail Immunogens versus a Monovalent Counterpart in Rhesus Macaques

Bowles, EJ; Schiffner, T; Rosario, M; Needham, GA; Ramaswamy, M; McGouran, J; Kessler, B; LaBranche, C; McMichael, AJ; Montefiori, D; Sattentau, QJ; Hanke, T; Stewart-Jones, GB.

PloS One, 2014, 9, (12), pe114709

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11. Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes

McGouran, JF; Gaertner, SR; Altun, M; Kramer, HB; Kessler, BM.

Chemistry & Biology, 2014, 20, 1447–1455,

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10. DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

 Lercher, L; McGouran, JF; Kessler, BM; Schofield, CJ; Davis, BG.

Angewandte Chemie (International ed. in English), 2013 52, (40), 10553-10558

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9. The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

Bush, J; Walport, L; McGouran, J; Leung, I; Berridge, G; Van Berkel, S; Basak, A; Kessler, B; Schofield, C.

Chemical Science, 2013, 4, (11), 4115-4120

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8. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors

New, M; Olzscha, H; Liu, G; Khan, O; Stimson, L; McGouran, J; Kerr, D; Coutts, A;  Kessler, B; Middleton, M; La Thangue, NB;

Cell Death & Differentiation, 2013, 20, 1306–131

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7. The PR/SET domain zinc finger protein Prdm4 regulates gene expression in  embryonic stem cells but plays a nonessential role in the developing mouse embryo

Bogani, D; Morgan, MA; Nelson, AC; Costello, I; McGouran, JF; Kessler, BM; Robertson, EJ;  Bikoff, EK.

Molecular and Cellular Biology, 2013, 33, (19), 3936-3950

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6. Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1

Zheng, S; Moehlenbrink, J; Lu, YC; Zalmas, LP; Sagum, CA; Carr, S; McGouran, JF; Alexander, L; Fedorov, O; Munro, S; Kessler, B; Bedford, MT; Yu, Q; La Thangue, NB.

Molecular Cell, 2013, 52, (1), 37-51

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5. Fluorescence-based active site probes for profiling deubiquitinating enzymes

McGouran, JF; Kramer, HB; Mackeen, MM; di Gleria, K; Altun, M; Kessler, BM

Organic & Biomolecular chemistry, 2012, 10, (17), 3379-3383

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4. Arginine methylation controls growth regulation by E2F-1.

Cho, EC; Zheng, S; Munro, S; Liu, G; Carr, SM; Moehlenbrink, J; Lu, YC; Stimson, L; Khan, O; Konietzny, R; McGouran, J; Coutts, AS; Kessler, B; Kerr, DJ; LaThangue, NB.

The EMBO journal, 2012, 31, (7), 2012, 1785-1797

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3. KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

Farcas, AM; Blackledge, NP; Sudbery, I; Long, HK; McGouran, JF; Rose, NR; Lee, S; Sims, D; Cerase, A; Sheahan, TW; Koseki, H; Brockdorff, N; Ponting, CP; Kessler, BM; Klose, RJ

eLife, 2012, 1, pe00205

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2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

Altun, M; Kramer, HB; Willems, LI; McDermott, JL; Leach, CA; Goldenberg, SJ; Kumar, KG; Konietzny, R; Fischer, R; Kogan, E; Mackeen, MM; McGouran, J; Khoronenkova, SV; Parsons, JL; Dianov, GL; Nicholson, B; Kessler, BM

Chemistry & Biology, 2011, 18, (11), 1401-1412

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1. Accessible sugars as asymmetric olefin epoxidation organocatalysts: glucosaminide ketones in the synthesis of terminal epoxides.

Boutureira, O; McGouran, JF; Stafford, RL; Emmerson, DP; Davis, BG

Organic & Biomolecular chemistry, 2009 7, (20), 4285-4288

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